Yale University

The Effects of HIV Disease in Pregnancy on the Development of Uninfected Children: an Exploratory Study to Understand Possible Mechanisms

Principle Investigator(s):

Funder: Albert McKern Trust Fund
Project period: 02/15/2012 - 02/15/2014
Grant Type: Research

Abstract Text:

The aims of the study are to:

  • Provide a greater understanding of the potential effects of the in-utero environment by conducting additional studies in the Yale laboratory of Dr Irina Buhimischi on preserved, frozen cord blood samples. These would include measures of inflammation (Haptoglobin, IL6 and sRAGE) and oxidative stress (TRAP).
  • Determine whether there are differences in development between HEU and non-HEU infants by following the established cohort to age 24 months and conducting developmental evaluations at 12 and 24 months.
  • Determine whether there is an association between markers of in-utero inflammation and child outcomes.
  • Determine the extent to which differences in social and maternal psychological characteristics of HIVinfected women might explain differences in child developmental and growth outcomes.

Outcome(s):