| Title | Artemether-lumefantrine exposure in HIV-infected Nigerian subjects on nevirapine-containing antiretroviral therapy. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Parikh, Sunil, Fatai Fehintola, Liusheng Huang, Alexander Olson, Waheed A. Adedeji, Kristin M. Darin, Gene D. Morse, Robert L. Murphy, Babafemi O. Taiwo, Olusegun O. Akinyinka, Isaac F. Adewole, Francesca T. Aweeka, and Kimberly K. Scarsi |
| Journal | Antimicrobial agents and chemotherapy |
| Date Published | 2015 Sep 21 |
| ISSN | 1098-6596 |
| Abstract | Co-administration of nevirapine-based antiretroviral therapy (ART) and artemether-lumefantrine is reported to result in variable changes in lumefantrine exposure. We conducted an intensive pharmacokinetic study in 11 HIV-infected adults receiving artemether-lumefantrine plus nevirapine-based ART and compared results to 16 historical HIV-negative adult controls. Exposure to artemether and lumefantrine was significantly lower, while dihydroartemisinin exposure was unchanged in subjects receiving nevirapine-based ART compared to controls. Nevirapine exposure was unchanged before and after artemether-lumefantrine. |
| Alternate Journal | Antimicrob. Agents Chemother. |
