Yale University

Do benefits of earlier antiretroviral treatment initiation outweigh harms for individuals at risk for poor adherence?

TitleDo benefits of earlier antiretroviral treatment initiation outweigh harms for individuals at risk for poor adherence?
Publication TypeJournal Article
Year of Publication2009
AuthorsBraithwaite, Scott R., Mark S. Roberts, Matthew Bidwell Goetz, Cynthia L. Gibert, Maria C. Rodriguez-Barradas, Kimberly Nucifora, and Amy C. Justice
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume48
Issue6
Pagination822-6
Date Published2009 Mar 15
ISSN1537-6591
KeywordsAdult, Antiviral Agents, Computer Simulation, HIV Infections, Humans, Life Expectancy, Medication Adherence, Middle Aged, Time Factors, Treatment Outcome
AbstractClinicians may defer antiretroviral treatment for patients with suboptimal adherence. We used a validated computer simulation of HIV disease progression to compare alternative treatment thresholds for patients with suboptimal adherence. Earlier treatment increased life expectancy across a wide adherence range (50%-100% of doses taken). Delaying treatment for patients with suboptimal adherence may not always be appropriate.
DOI10.1086/528859
Alternate JournalClin. Infect. Dis.

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