Yale University

Early ART Results in Greater Immune Reconstitution Benefits in HIV-Infected Infants: Working with Data Missingness in a Longitudinal Dataset.

TitleEarly ART Results in Greater Immune Reconstitution Benefits in HIV-Infected Infants: Working with Data Missingness in a Longitudinal Dataset.
Publication TypeJournal Article
Year of Publication2015
AuthorsAzzoni, Livio, Russell Barbour, Emmanouil Papasavvas, Deborah K. Glencross, Wendy S. Stevens, Mark F. Cotton, Avy Violari, and Luis J. Montaner
JournalPloS one
Volume10
Issue12
Paginatione0145320
Date Published2015
ISSN1932-6203
AbstractEarly initiation of anti-retroviral treatment (ART) decreases mortality as compared to deferred treatment, but whether it preserves immune cells from early loss or promotes their recovery remains undefined. Determination of complex immunological endpoints in infants is often marred by missing data due to missed visits and/or inadequate sampling. Specialized methods are required to address missingness and facilitate data analysis.
DOI10.1371/journal.pone.0145320
Alternate JournalPLoS ONE

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