%0 Journal Article %J Blood %D 2011 %T A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease. %A Vanasse, Gary J %A Jeong, Jee-Yeong %A Tate, Janet %A Bathulapalli, Harini %A Anderson, Damon %A Steen, Hanno %A Fleming, Mark %A Mattocks, Kristin %A Telenti, Amalio %A Fellay, Jacques %A Justice, Amy C %A Berliner, Nancy %K Adult %K Aged %K Anemia %K Anti-Retroviral Agents %K Cohort Studies %K Female %K Genetic Predisposition to Disease %K Genetic Variation %K Hemoglobins %K HIV Infections %K Humans %K Leptin %K Linkage Disequilibrium %K Male %K Middle Aged %K Polymorphism, Single Nucleotide %K Prevalence %K Promoter Regions, Genetic %K Veterans %N 20 %P 5401-8 %R 10.1182/blood-2011-06-362194 %V 118 %X To study factors associated with anemia and its effect on survival in HIV-infected persons treated with modern combined antiretroviral therapy (cART), we characterized the prevalence of anemia in the Veterans Aging Cohort Study (VACS) and used a candidate gene approach to identify proinflammatory gene single nucleotide polymorphisms (SNPs) associated with anemia in HIV disease. The study comprised 1597 HIV(+) and 865 HIV(-) VACS subjects with DNA, blood, and annotated clinical data available for analysis. Anemia was defined according to World Health Organization criteria (hemoglobin < 13 g/dL and < 12 g/dL in men and women, respectively). The prevalence of anemia in HIV(+) and HIV(-) subjects was 23.1% and 12.9%, respectively. Independent of HIV status, anemia was present in 23.4% and 8% in blacks and whites, respectively. Analysis of our candidate genes revealed that the leptin -2548 G/A SNP was associated with anemia in HIV(+), but not HIV(-), patients, with the AA and AG genotypes significantly predicting anemia (P < .003 and P < .039, respectively, logistic regression). This association was replicated in an independent cohort of HIV(+) women. Our study provides novel insight into the association between genetic variability in the leptin gene and anemia in HIV(+) individuals. %8 2011 Nov 17