%0 Journal Article %J The American journal of drug and alcohol abuse %D 2011 %T Tipranavir/ritonavir induction of buprenorphine glucuronide metabolism in HIV-negative subjects chronically receiving buprenorphine/naloxone. %A Bruce, R Douglas %A Moody, David E %A Fang, Wenfang B %A Chodkowski, Diane %A Andrews, Laurie %A Friedland, Gerald H %K Adult %K Buprenorphine %K Drug Interactions %K Female %K HIV Seronegativity %K Humans %K Male %K Metabolic Detoxication, Drug %K Middle Aged %K Naloxone %K Narcotic Antagonists %K Opioid-Related Disorders %K Pyridines %K Pyrones %K Ritonavir %N 4 %P 224-8 %R 10.1097/QAI.0b013e3181fbc94f %V 37 %X Previous reports on the pharmacokinetic of tipranavir (TPV) and buprenorphine (BUP)/ naloxone found that coadministration resulted in an 80% reduction in the area under the curve AUC of the primary BUP metabolite, norBUP, without any pharmacodynamic consequences. This study was conducted to characterize how tipranivir/ritonavir effects the glucuronide metabolites of BUP and may explain the reduction in the norBUP. %8 2011 Jul