%0 Journal Article %J BioMed research international %D 2015 %T CD8 (+) T-Cells Count in Acute Myocardial Infarction in HIV Disease in a Predominantly Male Cohort. %A Badejo, Oluwatosin A %A Chang, Chung-Chou %A So-Armah, Kaku A %A Tracy, Russell P %A Baker, Jason V %A Rimland, David %A Butt, Adeel A %A Gordon, Adam J %A Rinaldo, Charles R %A Kraemer, Kevin %A Samet, Jeffrey H %A Tindle, Hilary A %A Goetz, Matthew B %A Rodriguez-Barradas, Maria C %A Bedimo, Roger %A Gibert, Cynthia L %A Leaf, David A %A Kuller, Lewis H %A Deeks, Steven G %A Justice, Amy C %A Freiberg, Matthew S %P 246870 %R 10.1155/2015/246870 %V 2015 %X Human Immunodeficiency Virus- (HIV-) infected persons have a higher risk for acute myocardial infarction (AMI) than HIV-uninfected persons. Earlier studies suggest that HIV viral load, CD4(+) T-cell count, and antiretroviral therapy are associated with cardiovascular disease (CVD) risk. Whether CD8(+) T-cell count is associated with CVD risk is not clear. We investigated the association between CD8(+) T-cell count and incident AMI in a cohort of 73,398 people (of which 97.3% were men) enrolled in the U.S. Veterans Aging Cohort Study-Virtual Cohort (VACS-VC). Compared to uninfected people, HIV-infected people with high baseline CD8(+) T-cell counts (>1065 cells/mm(3)) had increased AMI risk (adjusted HR = 1.82, P < 0.001, 95% CI: 1.46 to 2.28). There was evidence that the effect of CD8(+) T-cell tertiles on AMI risk differed by CD4(+) T-cell level: compared to uninfected people, HIV-infected people with CD4(+) T-cell counts ≥200 cells/mm(3) had increased AMI risk with high CD8(+) T-cell count, while those with CD4(+) T-cell counts <200 cells/mm(3) had increased AMI risk with low CD8(+) T-cell count. CD8(+) T-cell counts may add additional AMI risk stratification information beyond that provided by CD4(+) T-cell counts alone. %8 2015