%0 Journal Article %J Antimicrobial agents and chemotherapy %D 2015 %T Artemether-lumefantrine exposure in HIV-infected Nigerian subjects on nevirapine-containing antiretroviral therapy. %A Parikh, Sunil %A Fehintola, Fatai %A Huang, Liusheng %A Olson, Alexander %A Adedeji, Waheed A %A Darin, Kristin M %A Morse, Gene D %A Murphy, Robert L %A Taiwo, Babafemi O %A Akinyinka, Olusegun O %A Adewole, Isaac F %A Aweeka, Francesca T %A Scarsi, Kimberly K %X Co-administration of nevirapine-based antiretroviral therapy (ART) and artemether-lumefantrine is reported to result in variable changes in lumefantrine exposure. We conducted an intensive pharmacokinetic study in 11 HIV-infected adults receiving artemether-lumefantrine plus nevirapine-based ART and compared results to 16 historical HIV-negative adult controls. Exposure to artemether and lumefantrine was significantly lower, while dihydroartemisinin exposure was unchanged in subjects receiving nevirapine-based ART compared to controls. Nevirapine exposure was unchanged before and after artemether-lumefantrine. %8 2015 Sep 21