Yale University

Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers.

TitlePharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers.
Publication TypeJournal Article
Year of Publication2010
AuthorsWallis, Robert S., Wesley M. Jakubiec, Vikas Kumar, Annette M. Silvia, Darcy Paige, Dessislava Dimitrova, Xiaoxi Li, Lynn Ladutko, Sheldon Campbell, Gerald Friedland, Mark Mitton-Fry, and Paul F. Miller
JournalThe Journal of infectious diseases
Volume202
Issue5
Pagination745-51
Date Published2010 Sep 1
ISSN1537-6613
KeywordsAcetamides, Antitubercular Agents, Dose-Response Relationship, Drug, Humans, Mycobacterium tuberculosis, Oxazolidinones, Serum Bactericidal Test, Treatment Outcome
AbstractThe oxazolidinone PNU-100480 is superior to linezolid against experimental murine tuberculosis. Two metabolites contribute to but do not fully account for its superiority. This study examined the safety, tolerability, pharmacokinetics, and mycobactericidal activity of single ascending doses of PNU-100480.
DOI10.3109/00952990.2011.568081
Alternate JournalJ. Infect. Dis.

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