Yale University

Using mechanistic models to simulate comparative effectiveness trials of therapy and to estimate long-term outcomes in HIV care.

TitleUsing mechanistic models to simulate comparative effectiveness trials of therapy and to estimate long-term outcomes in HIV care.
Publication TypeJournal Article
Year of Publication2010
AuthorsRoberts, Mark S., Kimberly A. Nucifora, and Scott R. Braithwaite
JournalMedical care
Volume48
Issue6 Suppl
PaginationS90-5
Date Published2010 Jun
ISSN1537-1948
KeywordsAcquired Immunodeficiency Syndrome, Anti-Retroviral Agents, CD4 Lymphocyte Count, Clinical Trials as Topic, Comparative Effectiveness Research, Computer Simulation, Drug Resistance, Viral, HIV Infections, Humans, Life Expectancy, Models, Statistical, Quality of Life, Time Factors, Treatment Outcome
AbstractIn HIV care, it is difficult to decide when to initiate therapy, which drugs to use for initial treatment, and which drugs to use if drug resistance develops. With hundreds of possible drug regimens available and variable patterns of drug resistance, randomized controlled trials cannot answer all HIV treatment decisions. Mechanistic models of HIV infection can be used to conduct virtual therapeutic trials with the goal of predicting outcomes, some of which are long-term and may not fall within the time frame of a typical therapeutic trial.
DOI10.1186/1758-2652-14-38
Alternate JournalMed Care

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