| Title | When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Cain, Lauren E., Roger Logan, James M. Robins, Jonathan A. C. Sterne, Caroline Sabin, Loveleen Bansi, Amy Justice, Joseph Goulet, Ard van Sighem, Frank de Wolf, Heiner C. Bucher, Viktor von Wyl, Anna Esteve, Jordi Casabona, Julia del Amo, Santiago Moreno, Remonie Seng, Laurence Meyer, Santiago Perez-Hoyos, Roberto Muga, Sara Lodi, Emilie Lanoy, Dominique Costagliola, and Miguel A. Hernan |
| Corporate Authors | HIV-CAUSAL Collaboration |
| Journal | Annals of internal medicine |
| Volume | 154 |
| Issue | 8 |
| Pagination | 509-15 |
| Date Published | 2011 Apr 19 |
| ISSN | 1539-3704 |
| Keywords | Acquired Immunodeficiency Syndrome, Anti-Retroviral Agents, Cause of Death, CD4 Lymphocyte Count, Developed Countries, Disease Progression, Drug Administration Schedule, Drug Therapy, Combination, HIV Infections, Humans, Observation, Proportional Hazards Models, Prospective Studies |
| Abstract | Most clinical guidelines recommend that AIDS-free, HIV-infected persons with CD4 cell counts below 0.350 × 10(9) cells/L initiate combined antiretroviral therapy (cART), but the optimal CD4 cell count at which cART should be initiated remains a matter of debate. |
| DOI | 10.7326/0003-4819-154-8-201104190-00001 |
| Alternate Journal | Ann. Intern. Med. |
