Yale University

The burden of infection with herpes simplex virus type 1 and type 2: seroprevalence study in Estonia.

TitleThe burden of infection with herpes simplex virus type 1 and type 2: seroprevalence study in Estonia.
Publication TypeJournal Article
Year of Publication2004
AuthorsUusk├╝la, Anneli, Mari Nygard-Kibur, Frances M. Cowan, Philippe Mayaud, Rebecca S. French, Jamie N. R. Robinson, and David W. G. Brown
JournalScandinavian journal of infectious diseases
Date Published2004
KeywordsAdolescent, Adult, Age Distribution, Child, Child, Preschool, Communicable Disease Control, Confidence Intervals, Cross-Sectional Studies, Estonia, Female, Herpes Genitalis, Herpes Simplex, Herpesvirus 1, Human, Herpesvirus 2, Human, Humans, Logistic Models, Male, Odds Ratio, Pregnancy, Risk Assessment, Seroepidemiologic Studies, Sex Distribution
AbstractInformation on age- and gender-specific prevalence of herpes simplex virus (HSV) types 1 and 2 infections is crucial to guide genital herpes control strategies. Such data are not available from the newly independent Eastern European countries. We present of study of the age- and gender-specific prevalence of HSV-1 and HSV-2 in low risk populations in Estonia. Serum samples from 1016 children, 794 first trimester antenatal women, and 1036 blood donors (462M, 574F) were tested for HSV IgG antibodies by type-specific HSV-1 and HSV-2 assays. High seroprevalence rates of HSV-1 among children, pregnant women and (non-paid) blood donors were found. HSV-2 infection was not detected among boys. Gender differences in HSV-2 seroprevalence rates among people of reproductive age were observed: higher rates were recorded among pregnant women (23%) and female blood donors (21%), compared to 11% among male blood donors. HSV-1 seroprevalence was high in adults. HSV-2 seroprevalence was higher among females than males and increased substantially with age. HSV-2 prevalence in these non-high risk populations was relatively high, and may indicate a risk for an impending sexually- and STI- driven HIV epidemic.
Alternate JournalScand. J. Infect. Dis.

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