| Title | Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | de Witte, Lot, Alexey Nabatov, and Teunis B. H. Geijtenbeek |
| Journal | Trends in molecular medicine |
| Volume | 14 |
| Issue | 1 |
| Pagination | 12-9 |
| Date Published | 2008 Jan |
| ISSN | 1471-4914 |
| Keywords | Antigens, CD, Cell Adhesion Molecules, Dendritic Cells, HIV Infections, Humans, Langerhans Cells, Lectins, C-Type, Mannose-Binding Lectins, Receptors, Cell Surface |
| Abstract | Dendritic cells (DCs) are thought to mediate HIV-1 transmission but it is becoming evident that different DC subsets at the sites of infection have distinct roles. In the genital tissues, two different DC subsets are present: the Langerhans cells (LCs) and the DC-SIGN(+)-DCs. Although DC-SIGN(+)-DCs mediate HIV-1 transmission, recent data demonstrate that LCs prevent HIV-1 transmission by clearing invading HIV-1 particles. However, this protective function of LCs is dependent on the function of the C-type lectin Langerin: blocking Langerin function by high virus concentrations enables HIV-1 transmission by LCs. Here, we will discuss the molecular mechanisms involved in HIV-1 transmission and viral clearance. A better understanding of these processes is crucial to understand and develop strategies to combat transmission. |
| DOI | 10.1002/hpm.1029 |
| Alternate Journal | Trends Mol Med |
