Yale University

Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission.

TitleDistinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission.
Publication TypeJournal Article
Year of Publication2008
Authorsde Witte, Lot, Alexey Nabatov, and Teunis B. H. Geijtenbeek
JournalTrends in molecular medicine
Volume14
Issue1
Pagination12-9
Date Published2008 Jan
ISSN1471-4914
KeywordsAntigens, CD, Cell Adhesion Molecules, Dendritic Cells, HIV Infections, Humans, Langerhans Cells, Lectins, C-Type, Mannose-Binding Lectins, Receptors, Cell Surface
AbstractDendritic cells (DCs) are thought to mediate HIV-1 transmission but it is becoming evident that different DC subsets at the sites of infection have distinct roles. In the genital tissues, two different DC subsets are present: the Langerhans cells (LCs) and the DC-SIGN(+)-DCs. Although DC-SIGN(+)-DCs mediate HIV-1 transmission, recent data demonstrate that LCs prevent HIV-1 transmission by clearing invading HIV-1 particles. However, this protective function of LCs is dependent on the function of the C-type lectin Langerin: blocking Langerin function by high virus concentrations enables HIV-1 transmission by LCs. Here, we will discuss the molecular mechanisms involved in HIV-1 transmission and viral clearance. A better understanding of these processes is crucial to understand and develop strategies to combat transmission.
DOI10.1002/hpm.1029
Alternate JournalTrends Mol Med

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