Title | Early ART Results in Greater Immune Reconstitution Benefits in HIV-Infected Infants: Working with Data Missingness in a Longitudinal Dataset. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Azzoni, Livio, Russell Barbour, Emmanouil Papasavvas, Deborah K. Glencross, Wendy S. Stevens, Mark F. Cotton, Avy Violari, and Luis J. Montaner |
Journal | PloS one |
Volume | 10 |
Issue | 12 |
Pagination | e0145320 |
Date Published | 2015 |
ISSN | 1932-6203 |
Abstract | Early initiation of anti-retroviral treatment (ART) decreases mortality as compared to deferred treatment, but whether it preserves immune cells from early loss or promotes their recovery remains undefined. Determination of complex immunological endpoints in infants is often marred by missing data due to missed visits and/or inadequate sampling. Specialized methods are required to address missingness and facilitate data analysis. |
DOI | 10.1371/journal.pone.0145320 |
Alternate Journal | PLoS ONE |