Yale University

The Epi-TAF for Tenofovir Disoproxil Fumarate?

TitleThe Epi-TAF for Tenofovir Disoproxil Fumarate?
Publication TypeJournal Article
Year of Publication2015
AuthorsWalensky, Rochelle P., Tim H. Horn, and David A. Paltiel
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Date Published2015 Dec 9
AbstractApproximately 84% of human immunodeficiency virus (HIV)-infected US residents on antiretroviral therapy currently receive some form of tenofovir disoproxil fumarate (TDF) as part of their HIV treatment regimen. The TDF analogue tenofovir alafenamide fumarate (TAF) has demonstrated equal efficacy but with decreased renal injury and bone mineral density loss compared with TDF. We examine how much more society ought to be willing to pay for TAF over TDF, in exchange for its improved toxicity profile. Using cost-effectiveness methods, we find that current conditions warrant an annual premium of up to $1000 over the average wholesale price (AWP) of TDF. Once generic coformulations of tenofovir/lamivudine become accessible, however, the appropriate premium for TAF will likely merit a downward adjustment, using generic TDF-based costs as the benchmark.
Alternate JournalClin. Infect. Dis.

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