@article {1090,
	title = {Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission.},
	journal = {Trends in molecular medicine},
	volume = {14},
	year = {2008},
	month = {2008 Jan},
	pages = {12-9},
	abstract = {Dendritic cells (DCs) are thought to mediate HIV-1 transmission but it is becoming evident that different DC subsets at the sites of infection have distinct roles. In the genital tissues, two different DC subsets are present: the Langerhans cells (LCs) and the DC-SIGN(+)-DCs. Although DC-SIGN(+)-DCs mediate HIV-1 transmission, recent data demonstrate that LCs prevent HIV-1 transmission by clearing invading HIV-1 particles. However, this protective function of LCs is dependent on the function of the C-type lectin Langerin: blocking Langerin function by high virus concentrations enables HIV-1 transmission by LCs. Here, we will discuss the molecular mechanisms involved in HIV-1 transmission and viral clearance. A better understanding of these processes is crucial to understand and develop strategies to combat transmission.},
	keywords = {Antigens, CD, Cell Adhesion Molecules, Dendritic Cells, HIV Infections, Humans, Langerhans Cells, Lectins, C-Type, Mannose-Binding Lectins, Receptors, Cell Surface},
	issn = {1471-4914},
	doi = {10.1002/hpm.1029},
	author = {de Witte, Lot and Nabatov, Alexey and Geijtenbeek, Teunis B H}
}
