@article {1092,
	title = {C-type lectin Mermaid inhibits dendritic cell mediated HIV-1 transmission to CD4+ T cells.},
	journal = {Virology},
	volume = {378},
	year = {2008},
	month = {2008 Sep 1},
	pages = {323-8},
	abstract = {Dendritic cells (DCs) are important in HIV-1 transmission; DCs capture invading HIV-1 through the interaction of the gp120 oligosaccharides with the C-type lectin DC-SIGN and migrate to the lymphoid tissues where HIV-1 is transmitted to T cells. Thus, the HIV-1 envelope glycoprotein gp120 is an attractive target to prevent interactions with DCs and subsequent viral transmission. Here, we have investigated whether the structural homologue of DC-SIGN, the nematode C-type lectin Mermaid can be used to prevent HIV-1 transmission by DCs. Our data demonstrate that Mermaid interacts with high mannose structures present on HIV-1 gp120 and thereby inhibits HIV-1 binding to DC-SIGN on DCs. Moreover, Mermaid inhibits DC-SIGN-mediated HIV-1 transmission from DC to T cells. We have identified Mermaid as a non-cytotoxic agent that shares the glycan specificity with DC-SIGN and inhibits DC-SIGN-gp120 interaction. The results are important for the anti-HIV-1 microbicide development directed at preventing DC-HIV-1 interactions.},
	keywords = {Animals, Anti-HIV Agents, CD4-Positive T-Lymphocytes, Cell Adhesion Molecules, Cell Line, Cells, Cultured, Dendritic Cells, Helminth Proteins, HIV Envelope Protein gp120, HIV-1, Humans, Lectins, C-Type, Nematoda, Protein Binding, Receptors, Cell Surface, Virus Attachment},
	issn = {1096-0341},
	doi = {10.1002/hpm.1029},
	author = {Nabatov, Alexey A and de Jong, Marein A W P and de Witte, Lot and Bulgheresi, Silvia and Geijtenbeek, Teunis B H}
}
