@article {1281,
	title = {Medication Persistence of HIV-infected Drug Users on Directly Administered Antiretroviral Therapy.},
	journal = {AIDS and behavior},
	year = {2011},
	month = {2011 Nov 22},
	abstract = {Patient and regimen persistence in HIV-infected drug users are largely unknown. We evaluated patterns of medication non-persistence among HIV-infected drug users enrolled in a prospective, 6-month randomized controlled trial of directly administered antiretroviral therapy (DAART). Medication-taking behavior was assessed via direct observation and MEMS data. Of 74 participants who initiated DAART, 59 (80\%) subjects were non-persistent with medication for 3 or more consecutive days. Thirty-one participants (42\%) had 2 or more episodes of non-persistence. Higher depressive symptoms were strongly associated with non-persistence episodes of~>=~3~days (AOR: 17.4, P~=~0.02) and~>=~7~days AOR: 5.4, P~=~0.04). High addiction severity (AOR 3.2, P~=~0.03) was correlated with non-persistence~>=~7~days, and injection drug use (AOR: 15.2, P~=~0.02) with recurrence of non-persistence~>=~3~days. Time to regimen change was shorter for NNRTI-based regimens compared to PI-based ones (HR: 3.0, P~=~0.03). There was no significant association between patterns of patient non-persistence and virological outcomes.},
	issn = {1573-3254},
	doi = {10.1007/s10461-011-0082-0},
	author = {Ing, Eileen C and Bae, Jason W and Maru, Duncan Smith-Rohrberg and Altice, Frederick L}
}
