@article {1383,
	title = {Interactions between buprenorphine and antiretrovirals. II. The protease inhibitors nelfinavir, lopinavir/ritonavir, and ritonavir.},
	journal = {Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
	volume = {43 Suppl 4},
	year = {2006},
	month = {2006 Dec 15},
	pages = {S235-46},
	abstract = {We examined drug interactions between buprenorphine, an opioid partial agonist available by prescription for treatment of opioid dependence, and the protease inhibitors (PIs) nelfinavir (NFV), ritonavir (RTV), and lopinavir/ritonavir (LPV/R). Opioid-dependent, buprenorphine/naloxone-maintained, human immunodeficiency virus (HIV)-negative volunteers (n=10 per PI) participated in 24-h pharmacokinetic studies, before and after administration of each PI. Symptoms of opiate withdrawal and excess were determined before and after PI administration. PI pharmacokinetics were determined and compared between opiate-dependent participants and healthy control participants (n=15 per PI). Administration of RTV, but not of NFV or LPV/R, resulted in a significant increase in the buprenorphine area under the concentration-time curve (AUC). Symptoms of opiate excess, however, were not observed. Buprenorphine had no significant effects on PI AUC. Adjustments of doses of either buprenorphine or NFV, LPV/R, or RTV are not likely to be necessary when these drugs are administered for the treatment of opioid dependence and HIV disease.},
	keywords = {Adult, Buprenorphine, Case-Control Studies, Cohort Studies, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Interactions, Female, HIV Protease Inhibitors, HIV Seronegativity, Humans, Lopinavir, Male, Narcotic Antagonists, Nelfinavir, Opioid-Related Disorders, Probability, Pyrimidinones, Reference Values, Risk Assessment, Ritonavir},
	issn = {1537-6591},
	doi = {10.3109/00952990.2011.568081},
	author = {McCance-Katz, Elinore F and Moody, David E and Smith, Patrick F and Morse, Gene D and Friedland, Gerald and Pade, Patricia and Baker, Jennifer and Alvanzo, Anika and Jatlow, Peter and Rainey, Petrie M}
}
