@article {1588,
	title = {The burden of infection with herpes simplex virus type 1 and type 2: seroprevalence study in Estonia.},
	journal = {Scandinavian journal of infectious diseases},
	volume = {36},
	year = {2004},
	month = {2004},
	pages = {727-32},
	abstract = {Information on age- and gender-specific prevalence of herpes simplex virus (HSV) types 1 and 2 infections is crucial to guide genital herpes control strategies. Such data are not available from the newly independent Eastern European countries. We present of study of the age- and gender-specific prevalence of HSV-1 and HSV-2 in low risk populations in Estonia. Serum samples from 1016 children, 794 first trimester antenatal women, and 1036 blood donors (462M, 574F) were tested for HSV IgG antibodies by type-specific HSV-1 and HSV-2 assays. High seroprevalence rates of HSV-1 among children, pregnant women and (non-paid) blood donors were found. HSV-2 infection was not detected among boys. Gender differences in HSV-2 seroprevalence rates among people of reproductive age were observed: higher rates were recorded among pregnant women (23\%) and female blood donors (21\%), compared to 11\% among male blood donors. HSV-1 seroprevalence was high in adults. HSV-2 seroprevalence was higher among females than males and increased substantially with age. HSV-2 prevalence in these non-high risk populations was relatively high, and may indicate a risk for an impending sexually- and STI- driven HIV epidemic.},
	keywords = {Adolescent, Adult, Age Distribution, Child, Child, Preschool, Communicable Disease Control, Confidence Intervals, Cross-Sectional Studies, Estonia, Female, Herpes Genitalis, Herpes Simplex, Herpesvirus 1, Human, Herpesvirus 2, Human, Humans, Logistic Models, Male, Odds Ratio, Pregnancy, Risk Assessment, Seroepidemiologic Studies, Sex Distribution},
	issn = {0036-5548},
	author = {Uusk{\"u}la, Anneli and Nygard-Kibur, Mari and Cowan, Frances M and Mayaud, Philippe and French, Rebecca S and Robinson, Jamie N R and Brown, David W G}
}
