@article {2330, title = {FIB-4 index is associated with hepatocellular carcinoma risk in HIV-infected patients.}, journal = {Cancer epidemiology, biomarkers \& prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology}, volume = {20}, year = {2011}, month = {2011 Dec}, pages = {2512-7}, abstract = {Chronic inflammation caused by hepatitis B virus infection, hepatitis C virus infection, and/or heavy alcohol use can lead to fibrosis, cirrhosis, and eventually hepatocellular carcinoma (HCC). FIB-4 is an index score calculated from platelet count, alanine transaminase, aspartate transaminase, and age that predicts fibrosis and cirrhosis. We hypothesized that high FIB-4 would be associated with development of HCC in HIV-infected persons, who are at high risk due to high prevalence of viral hepatitis and alcohol consumption, and possibly due to HIV infection itself.}, keywords = {Adult, Age Factors, Aged, Alanine Transaminase, Aspartate Aminotransferases, Biological Markers, Carcinoma, Hepatocellular, Cohort Studies, Female, HIV Infections, Humans, Liver Function Tests, Liver Neoplasms, Male, Middle Aged, Platelet Count, Risk Factors}, issn = {1538-7755}, doi = {10.1158/1055-9965.EPI-11-0582}, author = {Park, Lesley S and Tate, Janet P and Justice, Amy C and Lo Re, Vincent and Lim, Joseph K and Br{\"a}u, Norbert and Brown, Sheldon T and Butt, Adeel A and Gibert, Cynthia and Goetz, Matthew Bidwell and Rimland, David and Rodriguez-Barradas, Maria C and Dubrow, Robert} }