@article {2651, title = {A complex systems approach to evaluate HIV prevention in metropolitan areas: preliminary implications for combination intervention strategies.}, journal = {PloS one}, volume = {7}, year = {2012}, month = {2012}, pages = {e44833}, abstract = {HIV transmission among injecting and non-injecting drug users (IDU, NIDU) is a significant public health problem. Continuing propagation in endemic settings and emerging regional outbreaks have indicated the need for comprehensive and coordinated HIV prevention. We describe the development of a conceptual framework and calibration of an agent-based model (ABM) to examine how combinations of interventions may reduce and potentially eliminate HIV transmission among drug-using populations.}, keywords = {Cities, Communicable Disease Control, Drug Users, Female, HIV Infections, Homosexuality, Humans, Injections, Male, Models, Statistical, Risk, Risk-Taking}, issn = {1932-6203}, doi = {10.1371/journal.pone.0044833}, author = {Marshall, Brandon D L and Paczkowski, Magdalena M and Seemann, Lars and Tempalski, Barbara and Pouget, Enrique R and Galea, Sandro and Friedman, Samuel R} }