@article {2691,
	title = {Medication persistence of HIV-infected drug users on directly administered antiretroviral therapy.},
	journal = {AIDS and behavior},
	volume = {17},
	year = {2013},
	month = {2013 Jan},
	pages = {113-21},
	abstract = {Patient and regimen persistence in HIV-infected drug users are largely unknown. We evaluated patterns of medication non-persistence among HIV-infected drug users enrolled in a prospective, 6-month randomized controlled trial of directly administered antiretroviral therapy (DAART). Medication-taking behavior was assessed via direct observation and MEMS data. Of 74 participants who initiated DAART, 59 (80\%) subjects were non-persistent with medication for 3 or more consecutive days. Thirty-one participants (42\%) had 2 or more episodes of non-persistence. Higher depressive symptoms were strongly associated with non-persistence episodes of >= 3 days (AOR: 17.4, P = 0.02) and >= 7 days AOR: 5.4, P = 0.04). High addiction severity (AOR 3.2, P = 0.03) was correlated with non-persistence >= 7 days, and injection drug use (AOR: 15.2, P = 0.02) with recurrence of non-persistence >= 3 days. Time to regimen change was shorter for NNRTI-based regimens compared to PI-based ones (HR: 3.0, P = 0.03). There was no significant association between patterns of patient non-persistence and virological outcomes.},
	keywords = {Adult, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Behavior, Addictive, CD4 Lymphocyte Count, Connecticut, Directly Observed Therapy, Drug Users, Female, HIV Infections, Humans, Interviews as Topic, Kaplan-Meier Estimate, Male, Medication Adherence, Proportional Hazards Models, Randomized Controlled Trials as Topic, RNA, Viral, Severity of Illness Index, Substance Abuse, Intravenous, Treatment Outcome, Viral Load},
	issn = {1573-3254},
	doi = {10.1521/aeap.2013.25.1.14},
	author = {Ing, Eileen C and Bae, Jason W and Maru, Duncan Smith-Rohrberg and Altice, Frederick L}
}
