@article {3226,
	title = {Tipranavir/ritonavir induction of buprenorphine glucuronide metabolism in HIV-negative subjects chronically receiving buprenorphine/naloxone.},
	journal = {The American journal of drug and alcohol abuse},
	volume = {37},
	year = {2011},
	month = {2011 Jul},
	pages = {224-8},
	abstract = {Previous reports on the pharmacokinetic of tipranavir (TPV) and buprenorphine (BUP)/ naloxone found that coadministration resulted in an 80\% reduction in the area under the curve AUC of the primary BUP metabolite, norBUP, without any pharmacodynamic consequences. This study was conducted to characterize how tipranivir/ritonavir effects the glucuronide metabolites of BUP and may explain the reduction in the norBUP.},
	keywords = {Adult, Buprenorphine, Drug Interactions, Female, HIV Seronegativity, Humans, Male, Metabolic Detoxication, Drug, Middle Aged, Naloxone, Narcotic Antagonists, Opioid-Related Disorders, Pyridines, Pyrones, Ritonavir},
	issn = {1097-9891},
	doi = {10.1097/QAI.0b013e3181fbc94f},
	author = {Bruce, R Douglas and Moody, David E and Fang, Wenfang B and Chodkowski, Diane and Andrews, Laurie and Friedland, Gerald H}
}
