@article {4230, title = {Psychosocial Predictors of Non-Adherence and Treatment Failure in a Large Scale Multi-National Trial of Antiretroviral Therapy for HIV: Data from the ACTG A5175/PEARLS Trial.}, journal = {PloS one}, volume = {9}, year = {2014}, month = {2014}, pages = {e104178}, abstract = {PEARLS, a large scale trial of antiretroviral therapy (ART) for HIV (nā€Š=ā€Š1,571, 9 countries, 4 continents), found that a once-daily protease inhibitor (PI) based regimen (ATV+DDI+FTC), but not a once-daily non-nucleoside reverse transcriptase inhibitor/nucleoside reverse transcriptase inhibitor (NNRTI/NRTI) regimen (EFV+FTC/TDF), had inferior efficacy compared to a standard of care twice-daily NNRTI/NRTI regimen (EFV+3TC/ZDV). The present study examined non-adherence in PEARLS.}, issn = {1932-6203}, doi = {10.1371/journal.pone.0104178}, author = {Safren, Steven A and Biello, Katie B and Smeaton, Laura and Mimiaga, Matthew J and Walawander, Ann and Lama, Javier R and Rana, Aadia and Nyirenda, Mulinda and Kayoyo, Virginia M and Samaneka, Wadzanai and Joglekar, Anjali and Celentano, David and Martinez, Ana and Remmert, Jocelyn E and Nair, Aspara and Lalloo, Umesh G and Kumarasamy, Nagalingeswaran and Hakim, James and Campbell, Thomas B} }