@article {4492,
	title = {CD8 (+) T-Cells Count in Acute Myocardial Infarction in HIV Disease in a Predominantly Male Cohort.},
	journal = {BioMed research international},
	volume = {2015},
	year = {2015},
	month = {2015},
	pages = {246870},
	abstract = {Human Immunodeficiency Virus- (HIV-) infected persons have a higher risk for acute myocardial infarction (AMI) than HIV-uninfected persons. Earlier studies suggest that HIV viral load, CD4(+) T-cell count, and antiretroviral therapy are associated with cardiovascular disease (CVD) risk. Whether CD8(+) T-cell count is associated with CVD risk is not clear. We investigated the association between CD8(+) T-cell count and incident AMI in a cohort of 73,398 people (of which 97.3\% were men) enrolled in the U.S. Veterans Aging Cohort Study-Virtual Cohort (VACS-VC). Compared to uninfected people, HIV-infected people with high baseline CD8(+) T-cell counts (>1065 cells/mm(3)) had increased AMI risk (adjusted HR = 1.82, P < 0.001, 95\% CI: 1.46 to 2.28). There was evidence that the effect of CD8(+) T-cell tertiles on AMI risk differed by CD4(+) T-cell level: compared to uninfected people, HIV-infected people with CD4(+) T-cell counts >=200 cells/mm(3) had increased AMI risk with high CD8(+) T-cell count, while those with CD4(+) T-cell counts <200 cells/mm(3) had increased AMI risk with low CD8(+) T-cell count. CD8(+) T-cell counts may add additional AMI risk stratification information beyond that provided by CD4(+) T-cell counts alone.},
	issn = {2314-6141},
	doi = {10.1155/2015/246870},
	author = {Badejo, Oluwatosin A and Chang, Chung-Chou and So-Armah, Kaku A and Tracy, Russell P and Baker, Jason V and Rimland, David and Butt, Adeel A and Gordon, Adam J and Rinaldo, Charles R and Kraemer, Kevin and Samet, Jeffrey H and Tindle, Hilary A and Goetz, Matthew B and Rodriguez-Barradas, Maria C and Bedimo, Roger and Gibert, Cynthia L and Leaf, David A and Kuller, Lewis H and Deeks, Steven G and Justice, Amy C and Freiberg, Matthew S}
}
