@article {5016,
	title = {Using observational data to emulate a randomized trial of dynamic treatment-switching strategies: an application to antiretroviral therapy.},
	journal = {International journal of epidemiology},
	year = {2015},
	month = {2015 Dec 31},
	abstract = {When a clinical treatment fails or shows suboptimal results, the question of when to switch to another treatment arises. Treatment switching strategies are often dynamic because the time of switching depends on the evolution of an individual{\textquoteright}s time-varying covariates. Dynamic strategies can be directly compared in randomized trials. For example, HIV-infected individuals receiving antiretroviral therapy could be randomized to switching therapy within 90 days of HIV-1 RNA crossing above a threshold of either 400 copies/ml (tight-control strategy) or 1000 copies/ml (loose-control strategy).},
	issn = {1464-3685},
	doi = {10.1093/ije/dyv295},
	author = {Cain, Lauren E and Saag, Michael S and Petersen, Maya and May, Margaret T and Ingle, Suzanne M and Logan, Roger and Robins, James M and Abgrall, Sophie and Shepherd, Bryan E and Deeks, Steven G and Gill, M John and Touloumi, Giota and Vourli, Georgia and Dabis, Fran{\c c}ois and Vandenhende, Marie-Anne and Reiss, Peter and van Sighem, Ard and Samji, Hasina and Hogg, Robert S and Rybniker, Jan and Sabin, Caroline A and Jose, Sophie and del Amo, Julia and Moreno, Santiago and Rodr{\'\i}guez, Benigno and Cozzi-Lepri, Alessandro and Boswell, Stephen L and Stephan, Christoph and P{\'e}rez-Hoyos, Santiago and Jarrin, Inma and Guest, Jodie L and d{\textquoteright}Arminio Monforte, Antonella and Antinori, Andrea and Moore, Richard and Campbell, Colin N J and Casabona, Jordi and Meyer, Laurence and Seng, R{\'e}monie and Phillips, Andrew N and Bucher, Heiner C and Egger, Matthias and Mugavero, Michael J and Haubrich, Richard and Geng, Elvin H and Olson, Ashley and Eron, Joseph J and Napravnik, Sonia and Kitahata, Mari M and Van Rompaey, Stephen E and Teira, Ram{\'o}n and Justice, Amy C and Tate, Janet P and Costagliola, Dominique and Sterne, Jonathan A C and Hern{\'a}n, Miguel A}
}
