@article {5313,
	title = {DNA Polymerase-γ R953C Mutant is Associated with ART-Induced Mitochondrial Toxicity.},
	journal = {Antimicrobial agents and chemotherapy},
	year = {2016},
	month = {2016 Jul 5},
	abstract = {We found a heterozygous C2857T mutation (R953C) in Polymerase-gamma (Pol-γ) in an HIV-infected patient with mitochondrial toxicity. The R953C Pol-γ mutant binding affinity for dCTP is 8-fold less compared with that of wild-type. R953C mutant has a 4-fold decrease in discrimination of analog nucleotide relative to wild-type. R953 is located on the O-helix that forms substrate dNTP binding site; the interactions between R953 with E1056 and Y986 may stabilize the O-helix and affect polymerase activity.},
	issn = {1098-6596},
	doi = {10.1128/AAC.00976-16 },
	author = {Li, Min and Mislak, Andrea C and Foli, Yram and Agbosu, Esinam and Bose, Vivek and Bhandari, Shreya and Szymanski, Michal R and Shumate, Christie K and Yin, Y Whitney and Anderson, Karen S and Paintsil, Elijah}
}
