@article {963,
	title = {MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells.},
	journal = {Molecular immunology},
	volume = {46},
	year = {2009},
	month = {2009 Jul},
	pages = {2309-16},
	abstract = {Mother-to-child transmission of human immunodeficiency virus-1 (HIV-1) occurs frequently via breast-feeding. HIV-1 targets DC-SIGN+ dendritic cells (DCs) in mucosal areas that allow efficient transmission of the virus to T cells. Here, we demonstrate that the epithelial mucin MUC1, abundant in milk, efficiently bound to DC-SIGN on DC. The O-linked glycans within the mucin domain contained Lewis X structures, that were specifically recognized by the receptor. Interestingly, MUC1 prevented DC-SIGN-mediated transmission of HIV-1 from DCs to CD4+ T cells. We hypothesize that repetitive units of Lewis X, within the mucin domain, play an important role in inhibiting transmission of HIV-1 from mother to child.},
	keywords = {Animals, Antigens, CD15, CD4-Positive T-Lymphocytes, Cell Adhesion Molecules, CHO Cells, Cricetinae, Cricetulus, Dendritic Cells, Female, HIV Envelope Protein gp120, HIV Infections, HIV-1, Humans, Infectious Disease Transmission, Vertical, Lectins, C-Type, Milk, Human, Mucin-1, Pregnancy, Receptors, Cell Surface},
	issn = {1872-9142},
	author = {Saeland, Eirikur and de Jong, Marein A W P and Nabatov, Alexey A and Kalay, Hakan and Geijtenbeek, Teunis B H and van Kooyk, Yvette}
}
