%0 Journal Article %J Pediatric transplantation %D 2009 %T Lymphocyte subset reconstitution patterns in children with small bowel transplantation induced with steroid-free rabbit anti-human thymocyte globulin. %A Talukdar, Anjan J %A Ashokkumar, Chethan %A Wilson, Patrick %A Gupta, Ankit %A Sun, Qing %A Boig, Linda %A Abu-Elmagd, Kareem %A Mazariegos, George %A Green, Michael %A Sindhi, Rakesh %K Adolescent %K Antilymphocyte Serum %K CD4-Positive T-Lymphocytes %K Child %K Child, Preschool %K Female %K Graft Survival %K Herpesvirus 4, Human %K Humans %K Immunosuppressive Agents %K Infant %K Intestine, Small %K Killer Cells, Natural %K Lymphocyte Subsets %K Male %K Organ Transplantation %K T-Lymphocytes %K T-Lymphocytes, Cytotoxic %K Tacrolimus %K Viral Load %K Young Adult %N 3 %P 353-9 %R 10.1086/528859 %V 13 %X Multiple measurements (n = 212) of lymphocyte subsets in 67 children treated with steroid-free Tacrolimus, and rabbit anti-human thymocyte globulin induction demonstrate early reconstitution of T-cytotoxic and NK cells. Reconstitution of CD4+ cells is complete after the second post-transplant year. During the period at risk for rejection, NK and T-cytotoxic cell counts are significantly higher among Rejectors. During periods at increased risk for EBV viral infection, CD4 counts bear a significant inverse relationship to EBV viral load in a subset of at-risk recipients. Rejection-prone children also demonstrate significantly higher counts of total lymphocytes, Tc and NK cells prior to SBTx, and may illustrate one basis for enhanced baseline immunocompetence. %8 2009 May