%0 Journal Article %J PloS one %D 2014 %T Psychosocial Predictors of Non-Adherence and Treatment Failure in a Large Scale Multi-National Trial of Antiretroviral Therapy for HIV: Data from the ACTG A5175/PEARLS Trial. %A Safren, Steven A %A Biello, Katie B %A Smeaton, Laura %A Mimiaga, Matthew J %A Walawander, Ann %A Lama, Javier R %A Rana, Aadia %A Nyirenda, Mulinda %A Kayoyo, Virginia M %A Samaneka, Wadzanai %A Joglekar, Anjali %A Celentano, David %A Martinez, Ana %A Remmert, Jocelyn E %A Nair, Aspara %A Lalloo, Umesh G %A Kumarasamy, Nagalingeswaran %A Hakim, James %A Campbell, Thomas B %N 8 %P e104178 %R 10.1371/journal.pone.0104178 %V 9 %X PEARLS, a large scale trial of antiretroviral therapy (ART) for HIV (nā€Š=ā€Š1,571, 9 countries, 4 continents), found that a once-daily protease inhibitor (PI) based regimen (ATV+DDI+FTC), but not a once-daily non-nucleoside reverse transcriptase inhibitor/nucleoside reverse transcriptase inhibitor (NNRTI/NRTI) regimen (EFV+FTC/TDF), had inferior efficacy compared to a standard of care twice-daily NNRTI/NRTI regimen (EFV+3TC/ZDV). The present study examined non-adherence in PEARLS. %8 2014