%0 Journal Article %J AIDS (London, England) %D 2016 %T Identification of HIV infection-related DNA methylation sites and advanced epigenetic aging in HIV+, treatment-naïve U.S. veterans. %A Nelson, Kristin N %A Hui, Qin %A Rimland, David %A Xu, Ke %A Freiberg, Matthew S %A Justice, Amy C %A Marconi, Vincent C %A Sun, Yan V %X HIV-positive individuals are at higher risk than healthy persons for aging-related diseases, including myocardial infarction and non-AIDS defining cancers. Recent evidence suggests that HIV infection may modulate changes in the host cell epigenome, and these changes represent a potential mechanism through which HIV infection accelerates aging. We assessed the difference in DNAm age, an aging marker involving multiple age-related CpG sites, among antiretroviral treatment (ART) naïve HIV-positive and HIV-negative individuals in a cohort of veterans from the Veterans Aging Cohort Study (VACS). %8 2016 Dec 05