Yale University

A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease.

TitleA polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease.
Publication TypeJournal Article
Year of Publication2011
AuthorsVanasse, Gary J., Jee-Yeong Jeong, Janet Tate, Harini Bathulapalli, Damon Anderson, Hanno Steen, Mark Fleming, Kristin Mattocks, Amalio Telenti, Jacques Fellay, Amy C. Justice, and Nancy Berliner
Date Published2011 Nov 17
KeywordsAdult, Aged, Anemia, Anti-Retroviral Agents, Cohort Studies, Female, Genetic Predisposition to Disease, Genetic Variation, Hemoglobins, HIV Infections, Humans, Leptin, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Single Nucleotide, Prevalence, Promoter Regions, Genetic, Veterans
AbstractTo study factors associated with anemia and its effect on survival in HIV-infected persons treated with modern combined antiretroviral therapy (cART), we characterized the prevalence of anemia in the Veterans Aging Cohort Study (VACS) and used a candidate gene approach to identify proinflammatory gene single nucleotide polymorphisms (SNPs) associated with anemia in HIV disease. The study comprised 1597 HIV(+) and 865 HIV(-) VACS subjects with DNA, blood, and annotated clinical data available for analysis. Anemia was defined according to World Health Organization criteria (hemoglobin < 13 g/dL and < 12 g/dL in men and women, respectively). The prevalence of anemia in HIV(+) and HIV(-) subjects was 23.1% and 12.9%, respectively. Independent of HIV status, anemia was present in 23.4% and 8% in blacks and whites, respectively. Analysis of our candidate genes revealed that the leptin -2548 G/A SNP was associated with anemia in HIV(+), but not HIV(-), patients, with the AA and AG genotypes significantly predicting anemia (P < .003 and P < .039, respectively, logistic regression). This association was replicated in an independent cohort of HIV(+) women. Our study provides novel insight into the association between genetic variability in the leptin gene and anemia in HIV(+) individuals.
Alternate JournalBlood

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