| Title | A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Vanasse, Gary J., Jee-Yeong Jeong, Janet Tate, Harini Bathulapalli, Damon Anderson, Hanno Steen, Mark Fleming, Kristin Mattocks, Amalio Telenti, Jacques Fellay, Amy C. Justice, and Nancy Berliner |
| Journal | Blood |
| Volume | 118 |
| Issue | 20 |
| Pagination | 5401-8 |
| Date Published | 2011 Nov 17 |
| ISSN | 1528-0020 |
| Keywords | Adult, Aged, Anemia, Anti-Retroviral Agents, Cohort Studies, Female, Genetic Predisposition to Disease, Genetic Variation, Hemoglobins, HIV Infections, Humans, Leptin, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Single Nucleotide, Prevalence, Promoter Regions, Genetic, Veterans |
| Abstract | To study factors associated with anemia and its effect on survival in HIV-infected persons treated with modern combined antiretroviral therapy (cART), we characterized the prevalence of anemia in the Veterans Aging Cohort Study (VACS) and used a candidate gene approach to identify proinflammatory gene single nucleotide polymorphisms (SNPs) associated with anemia in HIV disease. The study comprised 1597 HIV(+) and 865 HIV(-) VACS subjects with DNA, blood, and annotated clinical data available for analysis. Anemia was defined according to World Health Organization criteria (hemoglobin < 13 g/dL and < 12 g/dL in men and women, respectively). The prevalence of anemia in HIV(+) and HIV(-) subjects was 23.1% and 12.9%, respectively. Independent of HIV status, anemia was present in 23.4% and 8% in blacks and whites, respectively. Analysis of our candidate genes revealed that the leptin -2548 G/A SNP was associated with anemia in HIV(+), but not HIV(-), patients, with the AA and AG genotypes significantly predicting anemia (P < .003 and P < .039, respectively, logistic regression). This association was replicated in an independent cohort of HIV(+) women. Our study provides novel insight into the association between genetic variability in the leptin gene and anemia in HIV(+) individuals. |
| DOI | 10.1182/blood-2011-06-362194 |
| Alternate Journal | Blood |
