| Title | The practice of office-based buprenorphine treatment of opioid dependence: is it associated with new patients entering into treatment? |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Sullivan, Lynn E., Marek Chawarski, Patrick G. O'Connor, Richard S. Schottenfeld, and David A. Fiellin |
| Journal | Drug and alcohol dependence |
| Volume | 79 |
| Issue | 1 |
| Pagination | 113-6 |
| Date Published | 2005 Jul |
| ISSN | 0376-8716 |
| Keywords | Adolescent, Adult, Aged, Buprenorphine, Cross-Sectional Studies, Female, Humans, Male, Mental Health Services, Middle Aged, Narcotic Antagonists, Office Visits, Opioid-Related Disorders, Physician's Practice Patterns |
| Abstract | Office-based buprenorphine holds the promise of bringing patients who have never received pharmacotherapy into treatment. In a cross-sectional and longitudinal analysis, we compared patients entering a clinical trial of buprenorphine in a Primary Care Clinic (PCC) and those entering a local Opioid Treatment Program (OTP) and we compared the clinical characteristics and treatment outcomes of PCC patients with no history of methadone treatment (new-to-treatment) to those with prior methadone treatment. PCC subjects (N=96) were enrolled in a 26-week randomized clinical trial of office-based buprenorphine/naloxone provided in a PCC. OTP subjects (N=94) were enrolled in methadone maintenance during the same time period. PCC subjects compared with OTP subjects were more likely to be male (77% versus 55%, p<0.01), full-time employed (46% versus 15%, p<0.001), have no history of methadone treatment (46% versus 61%, p<0.05), have fewer years of opioid dependence (10 versus 15, p<0.001), and lower rates of injection drug use (IDU) (44% versus 60%, p=0.03). The new-to-treatment PCC subjects were younger (36 years versus 41 years, p=0.001), more likely to be white (77% versus 57%, p=0.04), had fewer years of opioid dependence (7 versus 14, p<0.001), were less likely to have a history of IDU (35% versus 54%, p=0.07), and had lower rates of hepatitis C (25% versus 61%, p=0.002) than subjects with prior methadone treatment. Abstinence and treatment retention were comparable in both groups. The results suggest that office-based treatment of opioid dependence is associated with new types of patients entering into treatment. Treatment outcomes with buprenorphine in a PCC do not vary based on history of prior methadone treatment. |
| DOI | 10.1111/j.1475-6773.2011.01335.x |
| Alternate Journal | Drug Alcohol Depend |
