Yale University

Two independent HIV Epidemics in St. Petersburg, Russia Revealed by Molecular Epidemiology.

TitleTwo independent HIV Epidemics in St. Petersburg, Russia Revealed by Molecular Epidemiology.
Publication TypeJournal Article
Year of Publication2014
AuthorsDukhovlinova, Elena, Alexey Masharsky, Olga Toussova, Sergei Verevochkin, Tatiana Solovyeva, Maria Meringof, Elijah Paintsil, Edward White, Russell Barbour, Robert Heimer, and Andrei Kozlov
JournalAIDS research and human retroviruses
Date Published2014 Nov 23
ISSN1931-8405
AbstractThe HIV epidemic in Russia, one of the world's fastest growing, has been concentrated mostly among people who inject drugs (PWID). We sought to explore the epidemiology of the epidemic in St. Petersburg by sampling from the highest risk groups of PWID and men who have sex with men (MSM) and use viral sequencing data to better understand the nature of the city's epidemic. Serological testing confirmed HIV prevalence among PWID in excess of 40%. All but 1 of 111 PWID whose blood samples were tested for genetic diversity were infected by subtype A virus, specifically by A-FSU strain. The remaining person was infected with a CRF-06cpx recombinant. Analysis of pairwise genetic distance among all PWID studied revealed an average of 3.3% sequence divergence, suggesting clonal introduction of the A-FSU strain and/or constraints on sequence divergence. HIV prevalence was less than 10% among MSM. All 17 sequences from HIV-infected MSM were found to be clade B virus with a much higher average sequence diversity of 15.7%. These findings suggest two independent epidemics with little overlap between the two highest at-risk populations, which will require different HIV prevention approaches.
Alternate JournalAIDS Res. Hum. Retroviruses

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