| Title | Antiretroviral therapy-induced toxicity is associated with increased mRNA expression of telomerase. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Li, Min, Yram Foli, Nana Y. Amakye, Taline Klein, Shanmugapriya Selvaraj, Lingeng Lu, and Elijah Paintsil |
| Journal | Journal of clinical pharmacology |
| Date Published | 2015 Apr 23 |
| ISSN | 1552-4604 |
| Abstract | The widespread use of combination antiretroviral therapy (cART) has dramatically decreased AIDS-associated morbidity and mortality in HIV-infected individuals (1) . However, HIV treatment-experienced patients have a high prevalence of aging-associated diseases such as malignancies and cardiovascular diseases (2) . Given the canonical role of the telomerase system in cellular aging, it has been implicated in the pathogenesis of these non-AIDS defining illnesses in HIV-infected individuals (3) . This article is protected by copyright. All rights reserved. |
| DOI | 10.1002/jcph.520 |
| Alternate Journal | J Clin Pharmacol |
