Yale University

Artemether-lumefantrine exposure in HIV-infected Nigerian subjects on nevirapine-containing antiretroviral therapy.

TitleArtemether-lumefantrine exposure in HIV-infected Nigerian subjects on nevirapine-containing antiretroviral therapy.
Publication TypeJournal Article
Year of Publication2015
AuthorsParikh, Sunil, Fatai Fehintola, Liusheng Huang, Alexander Olson, Waheed A. Adedeji, Kristin M. Darin, Gene D. Morse, Robert L. Murphy, Babafemi O. Taiwo, Olusegun O. Akinyinka, Isaac F. Adewole, Francesca T. Aweeka, and Kimberly K. Scarsi
JournalAntimicrobial agents and chemotherapy
Date Published2015 Sep 21
ISSN1098-6596
AbstractCo-administration of nevirapine-based antiretroviral therapy (ART) and artemether-lumefantrine is reported to result in variable changes in lumefantrine exposure. We conducted an intensive pharmacokinetic study in 11 HIV-infected adults receiving artemether-lumefantrine plus nevirapine-based ART and compared results to 16 historical HIV-negative adult controls. Exposure to artemether and lumefantrine was significantly lower, while dihydroartemisinin exposure was unchanged in subjects receiving nevirapine-based ART compared to controls. Nevirapine exposure was unchanged before and after artemether-lumefantrine.
Alternate JournalAntimicrob. Agents Chemother.

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