Yale University

A novel approach to defining the relationship between lung function and symptom status in asthma.

TitleA novel approach to defining the relationship between lung function and symptom status in asthma.
Publication TypeJournal Article
Year of Publication2002
AuthorsKuntz, Karen M., Barrett T. Kitch, Anne L. Fuhlbrigge, David A. Paltiel, and Scott T. Weiss
JournalJournal of clinical epidemiology
Volume55
Issue1
Pagination11-8
Date Published2002 Jan
ISSN0895-4356
KeywordsAdult, Asthma, Clinical Trials as Topic, Forced Expiratory Volume, Humans, Linear Models, Predictive Value of Tests, Severity of Illness Index
AbstractWe present a novel approach to estimating functional relationships between forced expiratory volume in 1 second (FEV(1)) and asthma-related symptoms on a population-wide basis. We used asthma-related clinical trials that reported estimates of mean lung function (measured as FEV(1) percent predicted) and symptoms (symptom score or percentage of symptom days or nighttime awakenings). Using average baseline values from each study in weighted linear regression analyses, we found a negative association between lung function and symptom score (P < 0.001) and the percentage of nighttime awakenings (P = 0.18), but no association between lung function and symptom days. We also found consistent relationships between the mean changes in lung function and symptoms at follow-up within the studies. Functional relationships between FEV(1) percent predicted and asthma-related symptoms can be useful for inferring the effect on the symptoms of a population associated with overall improvements in lung function.
DOI10.1111/j.1524-4733.2010.00763.x
Alternate JournalJ Clin Epidemiol

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