| Title | PDC and functional HIV Gag p55-specific T cells before treatment interruption can inform set-point plasma HIV viral load after treatment interruption in Chronically Suppressed HIV-1(+) Subjects. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Papasavvas, Emmanouil, Andrea Foulkes, Xiangfan Yin, Jocelin Joseph, Brian Ross, Livio Azzoni, Jay R. Kostman, Karam Mounzer, Jane Shull, and Luis J. Montaner |
| Journal | Immunology |
| Date Published | 2015 Feb 12 |
| ISSN | 1365-2567 |
| Abstract | The identification of immune correlates of HIV control is important for the design of immunotherapies that could support CURE or antiretroviral therapy (ART) intensification-related strategies. ART interruptions may facilitate this task via exposure of an ART partially reconstituted immune system to endogenous virus. We investigated the relationship between set-point plasma HIV viral load (VL) during an ART interruption and innate/adaptive parameters prior or after interruption. Dendritic cell (DC), natural killer (NK) cell and HIV Gag p55-specific T cell functional responses were measured in paired cryo-preserved peripheral blood mononuclear cells (PBMC) obtained at the beginning (on ART) and at set-point of an open-ended interruption from 31 ART-suppressed chronically HIV-1(+) subjects. Spearman correlation and linear regression modeling were used. Frequencies of plasmacytoid DC (PDC), and HIV Gag p55-specific CD3(+) /CD4(-) /perforin(+) /IFN-γ(+) cells at the beginning of interruption associated negatively with set-point plasma VL. Inclusion of both variables with interaction into a model resulted in the best fit (adjusted R(2) =0.6874). Frequencies of PDC or HIV Gag p55-specific CD3(+) /CD4(-) /CSFE(lo) /CD107a(+) cells at set-point associated negatively with set-point plasma VL. The dual contribution of PDC and anti-HIV T cell responses to viral control, supported by our models, suggests that these variables may serve as immune correlates of viral control and could be integrated in CURE or ART-intensification strategies. This article is protected by copyright. All rights reserved. |
| DOI | 10.1111/imm.12452 |
| Alternate Journal | Immunology |
