| Title | Surgical stress-induced immune cell redistribution profiles predict short-term and long-term postsurgical recovery. A prospective study. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Rosenberger, Patricia H., Jeannette R. Ickovics, Elissa Epel, Eric Nadler, Peter Jokl, John P. Fulkerson, Jean M. Tillie, and Firdaus S. Dhabhar |
| Journal | The Journal of bone and joint surgery. American volume |
| Volume | 91 |
| Issue | 12 |
| Pagination | 2783-94 |
| Date Published | 2009 Dec |
| ISSN | 1535-1386 |
| Keywords | Arthroscopy, Female, Humans, Knee, Leukocytes, Longitudinal Studies, Lymphocytes, Male, Menisci, Tibial, Monocytes, Neutrophils, Predictive Value of Tests, Prognosis, Prospective Studies, Recovery of Function, Stress, Physiological |
| Abstract | The experience of undergoing surgery is known to induce a short-term, fight-or-flight physiological stress response. As an optimum immune response at the site of surgery would enhance tissue repair, we examined surgical stress-induced immune cell redistribution profiles as predictors, and potential mediators, of short and long-term postoperative recovery. We tested the a priori hypothesis that predefined adaptive immune cell redistribution profiles observed during surgery will predict enhanced postoperative recovery. |
| DOI | 10.1007/s10995-010-0650-3 |
| Alternate Journal | J Bone Joint Surg Am |
