Yale University

Surgical stress-induced immune cell redistribution profiles predict short-term and long-term postsurgical recovery. A prospective study.

TitleSurgical stress-induced immune cell redistribution profiles predict short-term and long-term postsurgical recovery. A prospective study.
Publication TypeJournal Article
Year of Publication2009
AuthorsRosenberger, Patricia H., Jeannette R. Ickovics, Elissa Epel, Eric Nadler, Peter Jokl, John P. Fulkerson, Jean M. Tillie, and Firdaus S. Dhabhar
JournalThe Journal of bone and joint surgery. American volume
Volume91
Issue12
Pagination2783-94
Date Published2009 Dec
ISSN1535-1386
KeywordsArthroscopy, Female, Humans, Knee, Leukocytes, Longitudinal Studies, Lymphocytes, Male, Menisci, Tibial, Monocytes, Neutrophils, Predictive Value of Tests, Prognosis, Prospective Studies, Recovery of Function, Stress, Physiological
AbstractThe experience of undergoing surgery is known to induce a short-term, fight-or-flight physiological stress response. As an optimum immune response at the site of surgery would enhance tissue repair, we examined surgical stress-induced immune cell redistribution profiles as predictors, and potential mediators, of short and long-term postoperative recovery. We tested the a priori hypothesis that predefined adaptive immune cell redistribution profiles observed during surgery will predict enhanced postoperative recovery.
DOI10.1007/s10995-010-0650-3
Alternate JournalJ Bone Joint Surg Am

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