Yale University

Tools to therapeutically harness the human antibody response.

TitleTools to therapeutically harness the human antibody response.
Publication TypeJournal Article
Year of Publication2012
AuthorsWilson, Patrick C., and Sarah F. Andrews
JournalNature reviews. Immunology
Date Published2012 Oct
KeywordsAnimals, Antibodies, Neutralizing, Antibodies, Viral, Antibody Formation, B-Lymphocytes, Epitopes, Humans, Virus Diseases
AbstractThe natural human antibody response is a rich source of highly specific, neutralizing and self-tolerant therapeutic reagents. Recent advances have been made in isolating and characterizing monoclonal antibodies that are generated in response to natural infection or vaccination. Studies of the human antibody response have led to the discovery of crucial epitopes that could serve as new targets in vaccine design and in the creation of potentially powerful immunotherapies. With a focus on influenza virus and HIV, herein we summarize the technological tools used to identify and characterize human monoclonal antibodies and describe how these tools might be used to fight infectious diseases.
Alternate JournalNat. Rev. Immunol.

External Links