| Title | Can life expectancy and QALYs be improved by a framework for deciding whether to apply clinical guidelines to patients with severe comorbid disease? |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Braithwaite, Scott R. |
| Journal | Medical decision making : an international journal of the Society for Medical Decision Making |
| Volume | 31 |
| Issue | 4 |
| Pagination | 582-95 |
| Date Published | 2011 Jul-Aug |
| ISSN | 1552-681X |
| Keywords | Blood Glucose, Colorectal Neoplasms, Comorbidity, Female, Humans, Life Expectancy, Middle Aged, Models, Theoretical, Practice Guidelines as Topic, Quality-Adjusted Life Years |
| Abstract | Guidelines with short-term harms and long-term benefits are often applied to chronically ill patients who may not benefit. The payoff time framework has been proposed (i.e., do not apply a guideline if a patient's life expectancy (LE) is shorter than when a guideline's cumulative incremental benefits first exceed its cumulative incremental harms), but its health impact is unclear. |
| DOI | 10.1186/1758-2652-14-38 |
| Alternate Journal | Med Decis Making |
