| Title | CCL3L1 copy number is a strong genetic determinant of HIV seropositivity in Caucasian intravenous drug users. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Huik, Kristi, Maarja Sadam, Tõnis Karki, Radko Avi, Tõnu Krispin, Piret Paap, Kristi Rüütel, Anneli Uusküla, Ave Talu, Katri Abel-Ollo, and Irja Lutsar |
| Journal | The Journal of infectious diseases |
| Volume | 201 |
| Issue | 5 |
| Pagination | 730-9 |
| Date Published | 2010 Mar |
| ISSN | 1537-6613 |
| Keywords | Adult, Chemokines, CC, Drug Users, Estonia, European Continental Ancestry Group, Female, Gene Dosage, Hepacivirus, Hepatitis C, HIV Seropositivity, Humans, Immunity, Innate, Male, Polymerase Chain Reaction, Substance Abuse, Intravenous |
| Abstract | A high copy number of CCL3L1, the most potent human immunodeficiency virus (HIV)-suppressive chemokine, associates with reduced HIV susceptibility. Whether CCL3L1 influences acquisition of multiple blood-borne infections (eg, hepatitis C virus [HCV], HIV, and hepatitis B virus [HBV] infections), which occur commonly among injection drug users (IDUs), is unknown. |
| DOI | 10.1007/s10461-009-9532-3 |
| Alternate Journal | J. Infect. Dis. |
