Yale University

CCL3L1 copy number is a strong genetic determinant of HIV seropositivity in Caucasian intravenous drug users.

TitleCCL3L1 copy number is a strong genetic determinant of HIV seropositivity in Caucasian intravenous drug users.
Publication TypeJournal Article
Year of Publication2010
AuthorsHuik, Kristi, Maarja Sadam, Tõnis Karki, Radko Avi, Tõnu Krispin, Piret Paap, Kristi Rüütel, Anneli Uusküla, Ave Talu, Katri Abel-Ollo, and Irja Lutsar
JournalThe Journal of infectious diseases
Volume201
Issue5
Pagination730-9
Date Published2010 Mar
ISSN1537-6613
KeywordsAdult, Chemokines, CC, Drug Users, Estonia, European Continental Ancestry Group, Female, Gene Dosage, Hepacivirus, Hepatitis C, HIV Seropositivity, Humans, Immunity, Innate, Male, Polymerase Chain Reaction, Substance Abuse, Intravenous
AbstractA high copy number of CCL3L1, the most potent human immunodeficiency virus (HIV)-suppressive chemokine, associates with reduced HIV susceptibility. Whether CCL3L1 influences acquisition of multiple blood-borne infections (eg, hepatitis C virus [HCV], HIV, and hepatitis B virus [HBV] infections), which occur commonly among injection drug users (IDUs), is unknown.
DOI10.1007/s10461-009-9532-3
Alternate JournalJ. Infect. Dis.

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