Yale University

Determinants of high-risk sexual behavior during post-exposure prophylaxis to prevent HIV infection.

TitleDeterminants of high-risk sexual behavior during post-exposure prophylaxis to prevent HIV infection.
Publication TypeJournal Article
Year of Publication2008
AuthorsGolub, Sarit A., Lisa Rosenthal, Daniel E. Cohen, and Kenneth H. Mayer
JournalAIDS and behavior
Date Published2008 Nov
KeywordsAdenine, Anti-HIV Agents, Deoxycytidine, Drug Therapy, Combination, HIV Infections, Homosexuality, Male, Humans, Interviews as Topic, Lamivudine, Male, Organophosphonates, Questionnaires, Reverse Transcriptase Inhibitors, Risk Factors, Risk-Taking, Sexual Partners, Treatment Outcome
AbstractMen who have sex with men (MSM) receiving non-occupational post-exposure prophylaxis (NPEP) to prevent HIV transmission completed interview-assisted questionnaires regarding high-risk behavior in the 6 months prior to NPEP and during the 28-day NPEP period. 21% of participants reported unprotected sex during NPEP, and 11% reported unprotected sex with HIV-positive or HIV status unknown partners. In univariate analyses, unprotected sex during NPEP was associated with prevention fatigue, depression, loss of loved ones to HIV, and a history of engagement with HIV/AIDS service organizations, e.g., receiving services from an HIV-related agency, donating money to HIV-related causes, and reading HIV-related magazines. Logistic regression analyses revealed that the strongest predictor of risk-taking during NPEP was HIV engagement. These data underscore the importance of combining chemoprophylaxis with behavioral interventions that support risk-reduction. Such interventions should not assume that those most engaged with HIV/AIDS service organizations are less likely to engage in risk behavior.
Alternate JournalAIDS Behav

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