| Title | Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV? |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Justice, Amy C., Matthew S. Freiberg, Russ Tracy, Lew Kuller, Janet P. Tate, Matthew Bidwell Goetz, David A. Fiellin, Gary J. Vanasse, Adeel A. Butt, Maria C. Rodriguez-Barradas, Cynthia Gibert, Kris Ann Oursler, Steven G. Deeks, and Kendall Bryant |
| Corporate Authors | VACS Project Team |
| Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
| Volume | 54 |
| Issue | 7 |
| Pagination | 984-94 |
| Date Published | 2012 Apr |
| ISSN | 1537-6591 |
| Keywords | Adult, Aged, Aged, 80 and over, Aging, Antigens, CD14, Biological Markers, Female, Fibrin Fibrinogen Degradation Products, HIV Infections, HIV-1, Humans, Interleukin-6, Male, Middle Aged, Prognosis, Survival Analysis |
| Abstract | When added to age, CD4 count and human immunodeficiency virus type 1 (HIV-1) RNA alone (Restricted Index), hemoglobin, FIB-4 Index, hepatitis C virus (HCV), and estimated glomerular filtration rate improve prediction of mortality. Weighted and combined, these 7 routine clinical variables constitute the Veterans Aging Cohort Study (VACS) Index. Because nonroutine biomarkers of inflammation (interleukin 6 [IL-6]), coagulation (D-dimer), and monocyte activation (sCD14) also predict mortality, we test the association of these indices and biomarkers with each other and with mortality. |
| DOI | 10.1093/cid/cir989 |
| Alternate Journal | Clin. Infect. Dis. |
