| Title | Drug interactions between opioids and antiretroviral medications: interaction between methadone, LAAM, and nelfinavir. |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | McCance-Katz, Elinore F., Petrie M. Rainey, Patrick Smith, Gene Morse, Gerald Friedland, Marc Gourevitch, and Peter Jatlow |
| Journal | The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions |
| Volume | 13 |
| Issue | 2 |
| Pagination | 163-80 |
| Date Published | 2004 Mar-Apr |
| ISSN | 1055-0496 |
| Keywords | Acquired Immunodeficiency Syndrome, Adult, Cytochrome P-450 Enzyme System, Drug Interactions, Female, HIV Protease Inhibitors, Humans, Male, Methadone, Methadyl Acetate, Narcotics, Nelfinavir, Substance-Related Disorders |
| Abstract | Understanding drug interactions between antiretrovirals and opiate therapies may decrease toxicities and enhance adherence, with improved HIV outcomes in injection drug users. We report results of a clinical pharmacology study designed to examine the interaction of the protease inhibitor, nelfinavir, with methadone and LAAM (N = 48). Nelfinavir decreased methadone exposure, but no withdrawal was observed over the five day study period. LAAM and dinorLAAM concentrations were decreased, while norLAAM concentrations were increased, with minimal overall change in LAAM/metabolite exposure. Methadone and LAAM did not affect nelfinavir concentrations, but methadone decreased M8 metabolite exposure. While no toxicities were observed, clinicians should be aware of the potential for drug interactions when patients require treatment with nelfinavir and these opiate medications. |
| DOI | 10.3109/00952990.2011.568081 |
| Alternate Journal | Am J Addict |
