| Title | Drug interactions of clinical importance among the opioids, methadone and buprenorphine, and other frequently prescribed medications: a review. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | McCance-Katz, Elinore F., Lynn E. Sullivan, and Srikanth Nallani |
| Journal | The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions |
| Volume | 19 |
| Issue | 1 |
| Pagination | 4-16 |
| Date Published | 2010 Jan-Feb |
| ISSN | 1521-0391 |
| Keywords | Buprenorphine, Cytochrome P-450 CYP2D6, Drug Interactions, Humans, Methadone, Opioid-Related Disorders, Prescription Drugs, Street Drugs, Substance-Related Disorders |
| Abstract | Drug interactions are a leading cause of morbidity and mortality. Methadone and buprenorphine are frequently prescribed for the treatment of opioid addiction. Patients needing treatment with these medications often have co-occurring medical and mental illnesses that require medication treatment. The abuse of illicit substances is also common in opioid-addicted individuals. These clinical realities place patients being treated with methadone and buprenorphine at risk for potentially toxic drug interactions. A substantial literature has accumulated on drug interactions between either methadone or buprenorphine with other medications when ingested concomitantly by humans. This review summarizes current literature in this area. |
| DOI | 10.1111/j.1530-0277.2011.01601.x |
| Alternate Journal | Am J Addict |
