| Title | Drug toxicity, HIV progression, or comorbidity of aging: does tipranavir use increase the risk of intracranial hemorrhage? |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Justice, Amy C., David S. Zingmond, Kirsha S. Gordon, Shawn L. Fultz, Joseph L. Goulet, Joseph T. King, Dawn M. Bravata, Hernan Valdez, Michael Kraft, and Kristin M. Mattocks |
| Corporate Authors | Veterans Aging Cohort Study Project Team |
| Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
| Volume | 47 |
| Issue | 9 |
| Pagination | 1226-30 |
| Date Published | 2008 Nov 1 |
| ISSN | 1537-6591 |
| Keywords | Adult, Age Factors, Anti-HIV Agents, California, Cohort Studies, Databases, Factual, Female, HIV Infections, Humans, Intracranial Hemorrhages, Male, Medicaid, Middle Aged, Pyridines, Pyrones, Risk Factors, United States, Veterans |
| Abstract | The US Food and Drug Administration has issued a warning that tipranavir may be associated with increased risk of intracranial hemorrhage. We studied 2 large cohorts to estimate the background rate of intracranial hemorrhage and compared it with rates reported among persons who had been exposed to tipranavir. |
| DOI | 10.1086/592302 |
| Alternate Journal | Clin. Infect. Dis. |
