| Title | MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Saeland, Eirikur, Marein A. W. P. de Jong, Alexey A. Nabatov, Hakan Kalay, Teunis B. H. Geijtenbeek, and Yvette van Kooyk |
| Journal | Molecular immunology |
| Volume | 46 |
| Issue | 11-12 |
| Pagination | 2309-16 |
| Date Published | 2009 Jul |
| ISSN | 1872-9142 |
| Keywords | Animals, Antigens, CD15, CD4-Positive T-Lymphocytes, Cell Adhesion Molecules, CHO Cells, Cricetinae, Cricetulus, Dendritic Cells, Female, HIV Envelope Protein gp120, HIV Infections, HIV-1, Humans, Infectious Disease Transmission, Vertical, Lectins, C-Type, Milk, Human, Mucin-1, Pregnancy, Receptors, Cell Surface |
| Abstract | Mother-to-child transmission of human immunodeficiency virus-1 (HIV-1) occurs frequently via breast-feeding. HIV-1 targets DC-SIGN+ dendritic cells (DCs) in mucosal areas that allow efficient transmission of the virus to T cells. Here, we demonstrate that the epithelial mucin MUC1, abundant in milk, efficiently bound to DC-SIGN on DC. The O-linked glycans within the mucin domain contained Lewis X structures, that were specifically recognized by the receptor. Interestingly, MUC1 prevented DC-SIGN-mediated transmission of HIV-1 from DCs to CD4+ T cells. We hypothesize that repetitive units of Lewis X, within the mucin domain, play an important role in inhibiting transmission of HIV-1 from mother to child. |
| Alternate Journal | Mol. Immunol. |
