| Title | Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Wallis, Robert S., Wesley M. Jakubiec, Vikas Kumar, Annette M. Silvia, Darcy Paige, Dessislava Dimitrova, Xiaoxi Li, Lynn Ladutko, Sheldon Campbell, Gerald Friedland, Mark Mitton-Fry, and Paul F. Miller |
| Journal | The Journal of infectious diseases |
| Volume | 202 |
| Issue | 5 |
| Pagination | 745-51 |
| Date Published | 2010 Sep 1 |
| ISSN | 1537-6613 |
| Keywords | Acetamides, Antitubercular Agents, Dose-Response Relationship, Drug, Humans, Mycobacterium tuberculosis, Oxazolidinones, Serum Bactericidal Test, Treatment Outcome |
| Abstract | The oxazolidinone PNU-100480 is superior to linezolid against experimental murine tuberculosis. Two metabolites contribute to but do not fully account for its superiority. This study examined the safety, tolerability, pharmacokinetics, and mycobactericidal activity of single ascending doses of PNU-100480. |
| DOI | 10.3109/00952990.2011.568081 |
| Alternate Journal | J. Infect. Dis. |
